Illness, Injury & Death
Generally, common sense should prevent you from suffering the majority of perils lurking on the periphery. But
Illness
Failing to regulate Temperature, or neglecting your characters Hunger, Thirst & Nutrition can result in contracting an illness.
Injuries
Failing to address severe injuries in a timely manner can result in a lethal injury if not addressed - this means either forever treating it medically and addressing the symptoms when they arise, or having a doctor provide you an Amputation, which will remove the injury entirely, at the cost of removing the afflicted extremity.